Specifically, in HCC, SETDB1 expression was negatively correlated with CD8+ cells (r = −0.229, p = 8.48 × 10−6), Th1 cells (r = −0.469, p < 2.2 × 10−16), NK cells (r = −0.349, p = 5.65 × 10−12), and monocytes (r = −0.453, p < 2.2 × 10−16) (Figure 6E). This evidence concerns the gene CD8A and hepatocellular carcinoma.