Univariate Cox regression analysis showed that the factors that affect the survival of HCC patients include T-stage (p < 0.001, HR = 2.126), M-stage (p = 0.017, HR = 4.077), pathologic stage (p < 0.001, HR = 2.090), and SETDB1 expression level (p = 0.008, HR = 1.342) (Table 2). The gene discussed is SETDB1; the disease is hepatocellular carcinoma.