NFKB1 and bronchopulmonary dysplasia: Also, in a hyperoxia-induced BPD rat model, 18b-Glycyrrhetinic acid treatment inhibited the activation of NF-κB and the NLRP3 inflammasome, decreased ROS level and pulmonary inflammation, improved alveolar development, and increased body weight of neonatal rats exposed to hyperoxia [156].