HLA-B and autoimmune disease: In reality, BD presents characteristics bordering on autoimmune diseases and auto-inflammatory conditions; like autoimmune diseases, it is closely related to alterations and mutations of the major histocompatibility complex (HLA), showing a close association with the HLA-B* allele 51 [57]; furthermore, it presents activated Th1 and Th17 cells and an overproduction of several pro-inflammatory cytokines [58].