CHI3L1 forms a complex with IL-13Rα2 and IL-13, activating several signaling pathways (MAPK/ERK, AKT/PKB, and Wnt/β-catenin) engaged in the regulation of numerous cellular processes such as apoptosis, inflammation, immune response, melanoma metastasis, and transforming growth factor β1 (TGF-β1) production [60]. The gene discussed is AKT1; the disease is melanoma.