EGFR and central nervous system cancer: The human glioma cell line U373MG, which expresses ΔEGFR or its kinase-deficient mutant with the EGFP reporter, shows the dynamics of glioma growth and its dependence on the corresponding mutations, as well as an increased expression of the KLHDC8A gene associated with the suppression of EGFR activity, which is presumably responsible for tumor recurrence [133].