Research indicates that mutations in genes associated with axonal transport, such as dynactin subunit 1 (DCTN1) [88], profilin 1 (PFN1) [89], alsin 2 (ALS2) [30], KIF5A [90,91], and tubulin alpha 4a (TUBA4A) [92], can cause impairments in axonal transport, potentially leading to the progression of ALS. Here, PFN1 is linked to amyotrophic lateral sclerosis.