ALS is broadly classified into familial and sporadic subtypes, of which the most common ALS mutant genes are the copper-zinc superoxide dismutase (SOD1), chromosome 9 open reading frame 72 (C9ORF72), fused in sarcoma (FUS), and TAR DNA-binding protein (TARDBP) [10]. The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.