Indeed, it has been observed in T98G glioblastoma, HSC-3 oral squamous cell carcinoma and MCF-7 breast adenocarcinoma cells that hypoxic conditions lead to an ~31–48% decrease in lat1 mRNA expression and that the expression could be restored by using an siRNA knockdown of hif-1α [79]. This evidence concerns the gene LAT and glioblastoma.