Indeed, there is still confusion as to whether there is a reliance on HR for the repair of BNCT-induced CDD driven by proteins such as MRN, BRCA1/2 and RAD51, whereas others propose roles for NHEJ involving either DNA-PKcs, Ku70/80 or PARP-1. The gene discussed is PRKDC; the disease is craniodiaphyseal dysplasia.