Bleomycin-induced Cxcl1 production in lungs and Cxcl1 levels correlated with neutrophilic airway inflammation in mice preceding pulmonary fibrosis [23,245,246,247] which were attenuated by the Cxcr2 antagonists [245,246] or endothelial glycosaminoglycans antagonism [23]. This evidence concerns the gene CXCR2 and pulmonary fibrosis.