IL2 and graft versus host disease: The suppressive effect of Tregs on GVHD is provided by contact-dependent and contact-independent mechanisms: cytolysis of effector cells (secretion of perforin and granzyme B); secretion of IL-10, TGF-β, and IL-35 immunosuppressive cytokines; depletion of IL-2 due to its greater consumption by Tregs due to high expression of CD25; induction of enzymatic breakdown of adenosine triphosphoric acid to adenosine; modulation of DC function both at the maturation stage and during the implementation of the antigen-presenting function [77].