ANGPTL4 and cancer: One of the functions of PPARβ/δ is angiogenesis [79]; it regulates both physiologically and pathological angiogenesis, where PPARβ/δ activates angiopoietin-like 4 (ANGPTL4), a secretory protein that participates in angiogenesis, cancer progression, and metastasis [80]; several other molecules besides ANGPTL4 are activated, such as platelet-derived growth factor receptor beta (Pdgfrb), platelet-derived growth factor subunit B (Pdgfb), and the tyrosinkinase KIT (c-Kit) [81].