IL6 and arthritic joint disease: Chondrocytes and ASCs could be co-cultured under experimental conditions simulating arthritis or exposure to pro-inflammatory molecules to investigate changes in the expression of chondroprotective and chondrolytic markers Future research should focus on evaluating the effects of IL-6 expression on cartilage regeneration in patients receiving clinical ASC treatments, as well as exploring how IL-6 expression in osteoclasts impacts the overall therapeutic efficacy of ASCs.