Interesting, four IFN and IL receptors genes, namely, IFNα-receptor 1 and 2 (IFNAR-1, IFNAR-2), IFNγ-R2 (IFNGR2), and IL-10 receptor β (IL10RB), are located on human chromosome 21 (HSA21), and in individuals with DS, their expression is ~1.5 times higher (proportional to the gene dosage effect of the trisomy), leading to an increased IFN sensitivity and an enhanced JAK-STAT pathway activation [52]. Here, IFNGR2 is linked to Dravet syndrome.