Studies of the JAK-STAT pathway in the Ts1Cje mouse model (a widely used mouse model of DS, trisomic for 94 genes located on mouse cromosome 16 [53]), which is characterized among other typical DS neurodevelompental alterations by an increased astrocyte number compared to wild-type animal, showed an alteration of JAK and STAT phosphorylation during prenatal and early postnatal development in the brain and in cortex-derived neurospheres [54,55]. The gene discussed is SOAT1; the disease is Dravet syndrome.