In addition, the Akt/mammalian target of the rapamycin (Akt/mTOR) signaling pathway, a ubiquitous serine/threonine kinase pathway involved in synaptogenesis, is upregulated in the brain tissue of young adults with DS [68] and in the hippocampal neurons of Ts1Cje mice [69]. This evidence concerns the gene MTOR and Dravet syndrome.