However, since the sodium potassium chloride cotransporter-1 (NKCC1) is one of the channels responsible for controlling the inhibitory homeostasis of GABAergic signals during brain development [81], and NKCC1 is expressed in various cell types, including astrocytes [82], the enhanced number of astrocytes in the trisomic brain can contribute to augmented NKCC1 expression in DS and to GABAergic dysregulation. This evidence concerns the gene SLC12A2 and Dravet syndrome.