Furthermore, RNA-sequencing analysis of astrocytes derived from DS patients reveals dysregulation of cell adhesion and extracellular matrix molecules, with notable alterations in the expression of several protocadherins (PCDHs) [73], confirming previous findings regarding γ-PCDH downregulated in postmortem DS fetal cortex [74]. The gene discussed is PCDH11X; the disease is Dravet syndrome.