Compared to CRC tissues without simultaneous higher expressions of TCF12 mRNA and MALAT1, the TCF12hiMALAT1hi CRC tissues were detected to have a statistically significantly higher expression of cyclin D1 mRNA (12.27 ± 0.68 vs. 11.93 ± 0.60, p = 0.001). The gene discussed is MALAT1; the disease is colorectal carcinoma.