The most common initial (“first-line”) therapies for IESS are adrenocorticotropic hormone (ACTH) or oral corticosteroids (OCSs); meanwhile, the gamma-aminobutyric acid (GABA) transaminase inhibitor, vigabatrin, seems to be particularly effective in children with IESS due to tuberous sclerosis complex, and it is favored by some clinicians for other etiologies as well [3]. Here, POMC is linked to tuberous sclerosis.