The most common severe AEs were hypertension (grades 1–4: 35% any grade, 18% grade 3–4), increased alanine aminotransferase (ALT) (45% any grade, 9% grades 3–4), increased aspartate aminotransferase (AST) (51% any grade, 8% grade 3–4), increased creatinine levels (37% any grade, 1% grade 3–4), and edemas (33% any grade, 0.3% grade 3–4). This evidence concerns the gene GPT and Hypertension.