The NPM1 mutation appears to be a late event in leukemia development and is usually associated with co-mutations such as DNA methyltransferase 3 alpha (DNMT3A), Fms-like tyrosine kinase 3 internal tandem duplication (FLT3-ITD) and isocitrate dehydrogenase (NADP(+)1/2) (IDH1/2), which also affect prognosis [2,3]. This evidence concerns the gene DNMT3A and leukemia.