AHR and metabolic dysfunction-associated steatohepatitis: Additionally, indole 3-acetate has been found to suppress the expression of AhR-regulated lipogenic enzymes, such as fatty acid synthase, as well as regulators of cholesterol metabolism like sterol regulatory element-binding protein-1c (SREBP-1c) in hepatocytes [107], which contributes to the prevention of NAFLD and NASH.