Increased concentrations of pro-inflammatory cytokines like interleukin 1 beta (IL-1β), IL-18, interferon gamma (IFN-γ), TNF-α, IL-12, and IL-6, along with NLR Family Pyrin Domain Containing 3 (NLRP3) in peritoneal macrophages upon exposure to LPS and suppresses Alum-induced peritonitis in vivo. This evidence concerns the gene IL18 and peritonitis.