An inhibitor of zinc metallopeptidase glutamate carboxypeptidase II, which was upregulated in IBD patients, was conjugated to DCA and alleviated inflammation in DSS-induced and Il10−/− models of colitis by lowering intestinal barrier permeability, normalizing tight junction protein expression, and suppressing procaspase-3 activation [224]. This evidence concerns the gene IL10 and colitis.