The disparities in the cumulative risk of any cancer and CRC between LSVH in Group 1A and Group 2 could be explained by the differing specific pathways and interactions of MMR genes in correcting DNA replication errors, as the MLH1 protein is more crucial for facilitating the repair process in conjunction with the PMS2 protein, while the MSH2 protein forms a dimer with either MSH6 or MSH3 proteins to recognize mismatches, which may contribute to the differing cancer risks observed [19,75]. The gene discussed is PMS2; the disease is colorectal carcinoma.