A previous LS study conducted in a European population by Harkness et al. (2015) estimated the cumulative risk of breast cancer by the age of 70 years to be approximately 18.6% (95% CI 11.3 to 25.9) for LSVH with MLH1 PV, while LSVH with MSH2 PV was about 11.2% (95% CI 1.4 to 21.0) by the age of 70 years [72]. This evidence concerns the gene MSH2 and breast cancer.