MLH1 and cancer: We observed a similar trend in risk of any cancer and CRC in LSVH with the MLH1:c.1528C>T PV, with male LSVH showing a significantly higher risk than female LSVH (log-rank test p = 0.010 and p < 0.001, respectively), with cumulative risks of 60.8–94.0% and 49.3–78.5% for any LS cancer, and 60.9–92.2% and 47.5–65.1% for CRC at the age of 50–70 years, respectively (Figure 6G,H and Table 4).