The observed significant difference in the age at CRC diagnosis between prevalent and incident cases of LSVH in Group 1B in our study population could be due to the fact that some of the individuals with the MLH1: c.1528C>T founder PV under our clinical surveillance were part of the clinical trial for 10 years on the daily intake of aspirin and resistant starch for the prevention of CRC [94,95,96]. This evidence concerns the gene MLH1 and colorectal carcinoma.