Particularly, the expression of ARL4C in such cancer cell lines as HCT116 colorectal cancer cells, A549 lung cancer cells, primary hepatocellular carcinoma HLE cells, and S2-CP8 cells (sequential passage of a human pancreatic cancer cell line through the lung of a nude mouse) is upregulated by the Wnt3a/β-catenin-dependent pathway and/or EGF- Ras-MAPK pathway (reviewed in [40]). Here, EGF is linked to hepatocellular carcinoma.