An evaluation of the diagnostic value of TNF-α soluble transmembrane receptors (sTNFR1 and sTNFR2) in endometriosis revealed that the levels of both receptors were significantly higher in the early stages of endometriosis, as classified by rASRM system, compared to the control group (sTNFR1, p < 0.01; sTNFR2, p < 0.04). The gene discussed is TNF; the disease is endometriosis.