Based on these considerations, herein we present a comprehensive review of the latest data aimed to address the roles played by the chemerin system in women with PCOS, with particular regard for PCOS-related features, comorbidities, and complications, to consolidate evidence about the association between chemerin and PCOS and to highlight its potential role as an upcoming biomarker and therapeutic target of the syndrome. Here, RARRES2 is linked to polycystic ovary syndrome.