The chronology of DAMP emission demonstrated by HG-3 and OSU-CLL cells subjected to SpiD3 treatment—starting with ecto-CALR, followed by extracellular ATP and HMGB1 release—is concordant with studies in the literature characterizing ICD in other tumor models [31,45,46]. The gene discussed is HMGB1; the disease is B-cell chronic lymphocytic leukemia.