PTGER3 and Hyperglycemia: In addition, other investigators have published that the atherothrombotic complications associated with hyperglycemia/diabetes may be mediated via a potentiation of the platelet activation and arterial thrombus formation via PGE2/EP3 signaling, since the blockade of the EP3 receptor activation reversed the hyperactivity of platelets and delayed thrombus formation in hyperglycemic mice [35].