The balance and expression between EP3 and EP4 receptors may constitute a pivotal role for the cardiovascular system, since it has been reported that the overexpression of EP3 receptor reduces cardiac function under basal conditions and that this is exacerbated after myocardial infarction [27], whereas the overexpression of EP4 improves cardiac function after a myocardial infarction [28]. Here, PTGER4 is linked to myocardial infarction.