Finally, the suppression of mitophagy (autophagic degradation of damaged mitochondria) in the NASH model, as shown by the reduced expression of PINK 1, Parkin, ULK1, BNIP3L, ATG 5, ATG 7 and ATG 12, was reversed by BM MSC EV administration, showing that EVs restored mitochondrial regulatory mechanisms that are perturbed during NASH [140]. Here, PRKN is linked to metabolic dysfunction-associated steatohepatitis.