Furthermore, an interesting evaluation of the exosomal surface antigen panel PaCIC (CD44v6, Tspan8, EpCAM, MET, and CD104) and serum exosome miRNA markers (miR-1246, miR-4644, miR-3976, and miR-4306) confirmed that the combination of different potential diagnostic tools can increase the sensitivity (1.00, CI: 0.95–1) and specificity (0.80, CI: 0.67–0.90) in the differentiation of PC from chronic pancreatitis, healthy controls, and non-pancreatic malignancies [178]. This evidence concerns the gene TSPAN8 and pachyonychia congenita.