Indeed, significantly higher levels of GPC1+ exosomes were observed in PC patients, both at early and late stages, compared with benign pancreatic disease and healthy controls (p < 0.0001), with absolute sensitivity (100%–95% CI: 98.1–100%) and specificity (100%–95% CI: 97.1–100%), a positive predictive value of 100% (95% CI: 98.1–100%), and a negative predictive value of 100% (95% CI: 86.8–100%) [165]. Here, GPC1 is linked to pachyonychia congenita.