The levels of C4b-binding protein a-chain, implicated in B cell proliferation and CD40 activation to reverse immune suppression and stimulate anti-tumor T cell responses; colfilin-1, implicated in chemotaxis, cell migration, and tumor cell invasion; and soluble gC1qR (sgC1qR), implicated in inflammation and malignancy, have been reported in a single study to be significantly elevated in PC compared to chronic pancreatitis or healthy controls [124,125,126]. This evidence concerns the gene CD40 and pachyonychia congenita.