Similarly, despite the high levels of serum trypsinogen-2 in patients with PC and the high sensitivity (100%) of heat shock protein 27 (HSP27), serum amyloid A (96.5%), and M2-pyruvate kinase (85%) in the detection of PC, unfortunately, the elevation of their levels in chronic pancreatitis and benign obstructive disease highlighted a significant lack of specificity of these markers in the most common differential diagnosis in clinical practice [109,110,111,112]. Here, PRSS2 is linked to chronic pancreatitis.