MUC4 has a role in early carcinogenesis and the early detection of PC; upregulation of MUC1, MUC2, and MUC5AC in PC; lower specificity of MUC7 because of its upregulation in IPMN and chronic pancreatitis. Here, MUC4 is linked to pancreatic intraductal papillary-mucinous neoplasm.