Although ApoB did not show any significant association with AMD (all p > 0.05, Figure 3A), a potential protective effect of ApoB on dry AMD was suggested by the IVW (OR = 0.91, 95% CI = 0.81–1.01, p = 0.074), weighted median (OR = 0.84, 95% CI = 0.72–0.98, p = 0.026), MR-Egger (OR = 0.86, 95% CI = 0.73–1.01, p = 0.064), MR-Egger (SIMEX) (OR = 0.86, 95% CI = 0.72–1.01, p = 0.065), and MR-PRESSO (OR = 0.91, 95% CI = 0.82–1.01, p = 0.064) methods (Figure 3B). The gene discussed is APOB; the disease is dry age related macular degeneration.