The research demonstrated that ONC treatment led to the upregulation of onco-suppressor microRNAs such as miR-20a-3p, miR-29a-3p, and miR-34a-5p, which corresponded to the downregulation of crucial onco-proteins involved in cell cycle regulation, survival pathways, and tumor metastatic potential, including cyclins D1 and A2, retinoblastoma protein, and cyclin-dependent-kinase-2. The gene discussed is PROS1; the disease is neoplasm.