IDH1 and central nervous system cancer: This analysis aimed to elucidate the molecular interactions of mucins with IDH1 and MGMT via EGFR, providing insights into their potential roles in glioma-related pathways and broader biological processes, and the resulting PPI enrichment p-value was <1.0 × 10−16, ranging from 0.99 to 0.42 (Supplemental Table S2).