CRP and diabetes mellitus: In a 12-year followed-up cohort of older adults with healthy cognition function (n = 1840) or MCI (n = 682), diabetes patients (HbA1c ≥ 7.5%) had a significantly higher (triple) risk of the progression of MCI to dementia (HR 3.30, 95%CI 1.02–9.93) accompanied by elevated CRP compared to normoglycemia, while those with diabetes with normal CRP showed an insignificant risk (HR 0.9, 0.48–1.67) [107].