As a kinase, the derepressed GSK3β increases phosphorylation of the tau protein in the damaged signaling pathway, ultimately contributing to CI in AD or poststroke dementia, etc. [26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48]. Here, MAPT is linked to Alzheimer disease.