ERBB3 and central nervous system cancer: Mutations in the gene that codes for the PIK3C2B protein are associated with the following diseases: high-grade glioma, Maffucci, and Hepatitis C. Mutations in the gene that codes for ERBB3 protein are associated with the following diseases: high-grade glioma, breast cancer, frontal myelination, enteric nervous system, and diabetes type 1.