The ten most frequently mutated genes, in order of frequency, for the 21 patients initially diagnosed with glioblastomas were EGFR (62%), TERT (62%), PDGFA (57%), TP53 43%, CDKN2A/B (29%), NF1 (24%), ALK (19%), EP300 (19%), KDR (19%), and MLL2 (19%). The gene discussed is ALK; the disease is glioblastoma.