Oligodendroglioma (Omut-IDH,codel-1p/19q,G3), in which TERT (3/4 Patients), CIC (3/4 Patients), FUBP1 (1/4 Patients), and NOTCH1 promoter (1/4 Patients), which corroborates the frequency of mutations in these genes in patients with high-grade gliomas. The gene discussed is NOTCH1; the disease is central nervous system cancer.