Univariate logistic regression analysis revealed that age, ALBI grade 3, tumor size ≥ 5 cm, AFP ≥ 400 ng/mL, early AFP response, AST > 4 0 U/L, alkaline phosphatase > 150 U/L, γ-glutamyl > 50 U/L, and absolute counts of white blood cells and monocytes were significant factors influencing PFS in liver cancer patients post-treatment. This evidence concerns the gene AFP and liver cancer.