Chi-square analysis of the early AFP response and early objective response rates revealed that the objective response rate (an indicator for evaluating the efficacy of cancer-treatment drugs, representing the proportion of patients whose tumors shrink to a certain standard after treatment, ORR) for early AFP responders was 39.5%, whereas for those with poor early AFP response, the ORR was only 10.1%, with a statistically significant difference (p = 0.014). This evidence concerns the gene AFP and cancer.