Additionally, Terrelonge et al. (2016) explored the role of CSF biomarkers in predicting cognitive impairment in early PD, revealing that lower baseline levels of CSF Aβ1–42 were significantly associated with a higher risk of cognitive impairment over a two-year period, while no significant associations were found for t-tau or p-tau181 [65]. Here, MAPT is linked to Cognitive impairment.