Taking into account that tumor exosomes may be dangerous to apply as a therapeutic agent, we loaded grapefruit vesicles with pure HSP70 and found that they efficiently activated innate pro-tumor immunity to colorectal cancer cells in vitro slowed down tumor growth and increased the survival rate in the animal model in vivo, stimulating specific antitumor CD8+ dependent immunity, which was accompanied by a reduction in the amount of pro-tumor cytokines, TGFβ-1 and IL-10. Here, TGFB1 is linked to neoplasm.