COL5A1 and aortic aneurysm: In murine models of abdominal aortic aneurysms, miR-29b-3p upregulation accelerated aneurysm expansion and increased rupture rates, accompanied by decreased expression of key ECM targets (e.g., Col1a1, Col3a1, Col5a1, and Eln), while inhibition of miR-29b-3p reduced aortic aneurysm progression [47].