Tumors with high T cell infiltration, high PD-L1 expression, and exhibiting high tumor mutational load (TMB) are categorized as ‘immunoinflammatory tumors.’ In ‘immune-excluded’ or ‘immune-rejected tumors,’ the cytotoxic T cells are often blocked at the surface without being able to enter cells to exert cytotoxic effects. Here, CD274 is linked to neoplasm.