ENG and endothelial dysfunction: Some of the noteworthy findings in the present study are the following: (1) higher doses and prolonged exposure to NaCl decrease the ECs’ metabolic activity and increase the ECs’ ROS production, thus making ECs an important source of ROS leading to endothelial dysfunction; (2) AngII exposure significantly reduces ROS production of ECs and can protect their metabolic activity to some extent; (3) AngII can modulate the expression of CAMs (as demonstrated by a decrease in ICAM-1 and endoglin expression with certain utilized doses of AngII).