In the univariate adjusted ORs, being young (OR 2.56, 95% CI 1.48–4.43), being female (OR 1.52, 95% CI 1.11–2.08), having IDH1 mutation (OR 15.92, 95% CI 7.30–34.75) and an oligodendroglioma diagnosis (OR 6.20, 95% CI 1.33–28.88) were associated with MGMT methylation. The gene discussed is MGMT; the disease is oligodendroglioma.