Through comparing the AML scRNA-seq data of HAVCR2 (+) with HAVCR2 (−) NK cells, signaling pathways involving in cell-killing and leukocyte mediated cytotoxicity of Gene Ontology (GO) analysis as well as natural killer cell mediated cytotoxicity of Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis were the most significantly enriched using the top 20 DEGs of up-regulated genes (Figure 1D,E). Here, HAVCR2 is linked to acute myeloid leukemia.