HAVCR2 and acute myeloid leukemia: By using starting cells from umbilical cord blood NK-derived induced pluripotent stem cells (iPSCs), Klaihmon et al. successfully established a single-cell clone of CAR-TIM3 iPSCs with enhanced anti-tumor activity against TIM3-positive AML cells compared with wild-type NK-like cells from parental iPSCs [40].