At the same time, the enhanced activation of iNOS suggests higher production of NO to facilitate the increase in ROS, in which “overproduction of NO by iNOS has been implicated in inflammation, rheumatoid arthritis, infection susceptibilities, irritable bowel syndrome (IBS), immune-type diabetes, stroke, sepsis, thrombosis, cancer, and multiple sclerosis (MS)” [35]. Here, NOS2 is linked to irritable bowel syndrome.