Analysis of the HPV DNA in the population by type of lesion showed an inverse behavior of the infection concerning anti-E5 antibodies since the lowest frequency was observed in the NL (14%, 21/150) and CIN1 (19.2%, 41/214) groups, with a clear upward trend for the CIN2 (27.8%, 20/72) and CIN3/CC (34.7%, 6/49) groups. The gene discussed is ARHGEF15; the disease is infection.