CRP and blood coagulation disease: This syndrome is characterized by the hyperactivation of tissue macrophages and the overproduction of inflammatory cytokines, such as IL-1, IL-6, and IL-8, and elevated levels of markers of inflammation, C-reactive protein (CRP), ferritin, and coagulation disorders involving D-dimer [12,13,14,15,16,17,18,19,20,21].