M1-like macrophages in atherosclerosis release proinflammatory cytokines, such as tumor necrosis factor-alpha (TNF-α), IL-1β, IL-6, nitric oxide (NO), IL-12, IL-23, CXCL8, CXCL9, CXCL10, CXCL11, CXCL16, CCL2, CCL3, and CCL5 [12,13]. The gene discussed is TNF; the disease is atherosclerosis.