FGF2 and ischemia: This process also leads to the release growth factors such as platelet-derived growth factor (PDGF-1), basic fibroblast growth factor (bFGF), and transforming growth factor-beta (TGF-β), promoting the proliferation and migration of smooth muscle cells, as well as collagen and elastin deposition, forming a fibrous cap that protects the necrotic core; this atheroma alters blood flow, causing ischemia [3,4].