l-SPD reduces l-DOPA-induced dyskinesia in the model of Parkinson’s disease [57], prevents methamphetamine-treated mice from memory deficits [40], and rescues memory deficit and synaptic plasticity in models of Alzheimer’s disease and depression via activating dopamine D1 receptor/PKA signaling pathway [37,39]. This evidence concerns the gene DRD1 and Alzheimer disease.