These parameters include age, obesity and BMI, etiology of infertility, duration of infertility, and serum hormonal levels FSH, LH total testosterone (tT), prolactin (PRL), and inhibin B [14,15,16,17,18,19,20,21,22,23,24,25]. The gene discussed is PRL; the disease is obesity due to melanocortin 4 receptor deficiency.