Additional research is needed to determine whether the ECD produced by ADAM10 cleavage serves other functions, as the expression of both RELT and ADAM10 is predicted to occur in several other tissues besides ameloblasts https://v23.proteinatlas.org/ENSG00000054967-RELT/tissue+cell+type (accessed on 15 November 2024), courtesy of the Human Protein Atlas [45], including ductal cells, which may be of relevance to BC. The gene discussed is RELT; the disease is breast cancer.