Galectin-3 (gal-3), a β-galactoside-binding lectin, encoded by the LGALS-3 gene, is involved in various inflammatory processes as one of the macrophage activators, in particular, in myocardial fibrosis, predicting and contributing to cardiac dysfunction and adverse cardiovascular outcomes in patients with coronary artery disease (CAD) [8]. The gene discussed is LGALS3; the disease is Myocardial fibrosis.