FLT3 and acute myeloid leukemia: Additionally, in acute myeloid leukemia (AML), higher expression levels of miR-155 have been associated with FLT3-ITD (FMS-like tyrosine kinase-3 internal tandem duplication) gene mutation, and several ongoing studies have investigated the role of miR-155 in minimal residual disease (MRD) monitoring or as a future therapeutic target [136].