In relation to routine diagnostic histopathology, immunohistochemical algorithms such as the Hans, the Choi, and the Tally algorithms, using different combinations of antibodies to germinal center or ABC B-cell-related proteins (e.g., Bcl-6, CD10, MUM1, LMO2 and GCET1 antibodies), have been developed for the classification of DLBCL on the basis of the cell of origin being GCB or non-GCB [14,15,16]. The gene discussed is BCL6; the disease is diffuse large B-cell lymphoma.