CDK2 and hepatocellular carcinoma: For instance, studies have shown that CDK1/2 and other markers of cell cycle progression play essential roles in maintaining genomic stability and mitigating genotoxic damage [54] and arrest in the G1 phase through the downregulation of cyclin D1 and CDK-2 genes exploring the anticancer potential of AgNPs and selenium SeNPs nanoparticles green-synthesized with berberine (Ber) in a human hepatocellular carcinoma cell line (HepG2) [55].