Our inquiry discovered significant upregulation of PGC expression in numerous cancers, including colon adenocarcinoma (COAD), rectum adenocarcinoma (READ), kidney renal clear cell carcinoma (KIRC), kidney renal papillary cell carcinoma (KIRP), glioblastoma (GBM), liver hepatocellular carcinoma (LIHC), lung adenocarcinoma (LUAD), lung squamous cell carcinoma (LUSC), skin cutaneous melanoma (SKCM), cholangiocarcinoma (CHOL), and uterine corpus endometrial carcinoma (UCEC), compared to their normal counterparts. Here, PGC is linked to cancer.